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AMG509 / 20230239

This is a study of evaluating the safety, tolerability, pharmacokinetics, and efficacy of AMG 509 in subjects with Metastatic Castration-Resistant Prostate Cancer.

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Open for recruitment

Trial summary

The overall aim of the trial is to evaluate the safety, tolerability, and pharmacokinetics (PK) of AMG 509 (monotherapy and in combination with abiraterone acetate and enzalutamide) and to evaluate preliminary efficacy. As of Protocol Amendment 10 (09 July 2025), only Parts 4A expansion, 6, and 7 are open to accrual.

Trial details

Short title

AMG509 / 20230239

Diagnosis

Prostate cancer

Type of treatment

Medical Oncology

Phase

III

Locations

Investigators

Principal Investigators

Who can participate

Clinical trials can have restrictive criteria of who can and can’t participate, talk to your healthcare provider if you are interested in this clinical trial.