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At Icon, we offer clinical trials across various tumour types and blood disorders, allowing patients access to new and emerging advances in treatment, find a trial that might be suitable for you.


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EMBRACE

A clinical research study testing olaparib, in Homologous recombination (HR) deficient metastatic breast and relapsed ovarian cancer in patients who do not have hereditary mutations in BReast CAncer susceptibility gene 1 and gene 2 (BRCA1 and BRCA2)

Locations

Wesley, Southport, South Brisbane, Chermside

Diagnosis

Breast cancer, Ovarian cancer

Open for recruitment
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SPAR

A clinical trial comparing Simvastatin to placebo, in addition to standard chemotherapy and radiotherapy, in preoperative treatment for patients with rectal cancer.

Locations

Gold Coast University Hospital

Diagnosis

Colorectal cancer

Open for recruitment
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OP-1250-001

A Dose Escalation/Expansion Study of Oral OP-1250 in Subjects With Advanced and/or Metastatic HR+, HER2- Breast Cancer

Locations

Wesley

Diagnosis

Breast cancer

Open for recruitment
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RLY-4008-101

A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients With Intrahepatic Cholangiocarcinoma (ICC) and Other Advanced Solid Tumors

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Open for recruitment
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OP-1250-002

A Phase 1 Dose Escalation and Expansion Open-label, Multicenter, Study of OP-1250 in Combination With the CDK4/6 Inhibitor Palbociclib in Adult Subjects With Advanced or Metastatic HR-positive, HER2-negative Breast Cancer

Locations

Wesley

Diagnosis

Breast cancer

Open for recruitment
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ABILITY

A Phase 1/2 Open Label, Dose Escalation and Expansion Study of MDNA11, IL-2 Superkine, Administered Alone or in Combination With Immune Checkpoint Inhibitor in Patients With Advanced Solid Tumors.

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Open for recruitment
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DB-1303-O-1001

A Phase 1/2a, Multicenter, Open-Label, Non-Randomized First in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of DB-1303 in Patients With Advanced/Metastatic Solid Tumors

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Open for recruitment
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BGB-290-103

A Phase 1b Study to Assess the Safety, Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Subjects With Locally Advanced or Metastatic Solid Tumors.

Locations

South Brisbane, Adelaide (Kurralta Park)

Diagnosis

Advanced solid tumours

Recruitment completed
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UPLIFT MER-XMT-1536-1

A Phase 1b/2, First-in-Human, Dose Escalation and Expansion Study of XMT-1536 In Patients With Solid Tumors Likely to Express NaPi2b

Locations

South Brisbane

Diagnosis

Ovarian cancer

Open for recruitment
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CodeBreak-101 20190135

A Phase 1b/2, Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Sotorasib Monotherapy and in Combination With Other Anti-cancer Therapies in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Open for recruitment
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ACT001-AU-004

A Phase 2 clinical trial to assess the safety and efficacy of ACT001 in combination with whole brain radiation therapy (WBRT) for participants with brain metastases from solid tumours.

Locations

Epworth Richmond, Moreland

Diagnosis

Brain cancer

Opening soon
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DESTINY-PanTumor02 D967VC00001

A Phase 2, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Trastuzumab Deruxtecan (T-DXd, DS-8201a) for the Treatment of Selected HER2 Expressing Tumors

Locations

South Brisbane, Wesley

Diagnosis

Advanced solid tumours

Open for recruitment
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TL-895-201

A Phase 2, Open-label, Multicenter Study of TL-895 in Subjects With Relapsed/Refractory Myelofibrosis, Janus Kinase Inhibitor Intolerant Myelofibrosis and Janus Kinase Inhibitor Treatment Ineligible Myelofibrosis

Locations

South Brisbane, Wesley, Chermside, Southport

Diagnosis

Myeloproliferative disorders

Recruitment completed
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BRUIN MCL-321

A Phase 3 Open-Label, Randomized Study of LOXO-305 Versus Investigator Choice of BTK Inhibitor in Patients With Previously Treated BTK Inhibitor Naïve Mantle Cell Lymphoma

Locations

Wesley

Diagnosis

Lymphoma – Hodgkin’s

Open for recruitment
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SHR-2002-102

A Phase I Clinical Study on the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of SHR-2002 Injection in Combination With SHR-1316 in Patients With Advanced Malignant Tumors

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Open for recruitment
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LM108-01-101

A Phase I/II, First-in-Human (FIH), Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of LM-108 as a Single Agent or in Combination With Anti-PD-1 Antibody in Subjects With Advanced Solid Tumours

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Open for recruitment
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SUCCEED_MG010-001

A phase I/II, open label, multi-centre study to assess the safety, tolerability, and efficacy of MG010 in combination with sorafenib in subjects with solid tumours who have failed existing treatments.

Locations

South Brisbane, Wesley, Chermside, Southport

Diagnosis

Advanced solid tumours

Open for recruitment
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CUPISCO-MX39795

A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site (CUPISCO)

Locations

Southport, Wesley, South Brisbane, Chermside

Diagnosis

Cancer-unknown origin

Open for recruitment
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OUTRUN

A Randomised Phase II Trial of Osimertinib With or Without Stereotactic Radiosurgery for EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) With Brain Metastases

Locations

Greenslopes

Diagnosis

Lung cancer

Open for recruitment
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GCT3013-05

A Randomized, Open-Label, Phase 3 Trial of Epcoritamab vs Investigator’s Choice Chemotherapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma

Locations

South Brisbane, Wesley

Diagnosis

Lymphoma – B-cell Non Hodgkin’s

Open for recruitment
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Impassion030 WO39391 Alexandra

A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer (IMpassion030)

Locations

Wesley, Adelaide (Kurralta Park)

Diagnosis

Breast cancer

Open for recruitment
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Checkmate-914 CA209-914

A Study Comparing Nivolumab, Nivolumab in Combination With Ipilimumab and Placebo in Participants With Localized Kidney Cancer Who Underwent Surgery to Remove Part of a Kidney (CheckMate 914)

Locations

South Brisbane, Wesley, Chermside

Diagnosis

Kidney cancer

Recruitment completed
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AK112-101

A Study of AK112, a PD-1/VEGF Bispecific Antibody, for Advanced Solid Tumors

Locations

South Brisbane, Adelaide (Kurralta Park)

Diagnosis

Advanced solid tumours

Open for recruitment
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AK119-102

A Study of AK119 (Anti-CD73) in Combination With AK104 in Subjects With Advanced Solid Tumors

Locations

South Brisbane, Adelaide (Kurralta Park)

Diagnosis

Advanced solid tumours

Open for recruitment
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CONTACT-03 WO41994

A Study of Atezolizumab in Combination With Cabozantinib Compared to Cabozantinib Alone in Participants With Advanced Renal Cell Carcinoma After Immune Checkpoint Inhibitor Treatment (CONTACT-03)

Locations

South Brisbane, Wesley, Chermside, Southport

Diagnosis

Kidney cancer

Open for recruitment
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RAGNAR 42756493CAN2002

A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations

Locations

South Brisbane, Wesley, Chermside, Southport

Diagnosis

Advanced solid tumours

Open for recruitment
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67652000PCR3002 AMPLITUDE

A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) (AMPLITUDE)

Locations

Chermside, South Brisbane, Southport, Wesley

Diagnosis

Prostate cancer

Open for recruitment
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Checkmate-7DX_CA209-7DX

A Study of Nivolumab or Placebo in Combination With Docetaxel in Men With Advanced Castration-resistant Prostate Cancer (CheckMate 7DX)

Locations

Chermside, Wesley, South Brisbane, Southport

Diagnosis

Prostate cancer

Open for recruitment
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CA224-104

A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)

Locations

Chermside, North Lakes, Wesley, South Brisbane, Southport

Diagnosis

Lung cancer

Open for recruitment
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TROPiCS-04

A Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician’s Choice in Participants With Metastatic or Locally Advanced Unresectable Urothelial Cancer.

Locations

Hobart, Wesley

Diagnosis

Urothelial cancer

Open for recruitment
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CANOVA M13-494

A Study of Venetoclax and Dexamethasone Compared With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma (CANOVA)

Locations

South Brisbane, Southport, Townsville, Wesley, Chermside

Diagnosis

Multiple myeloma

Open for recruitment
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ABSK043-101

A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK043 in Patients With Advanced Solid Tumor

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Open for recruitment
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M19-037

A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors

Locations

South Brisbane, Wesley

Diagnosis

Advanced solid tumours, Breast cancer

Open for recruitment
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liDERA

A study to evaluate the Efficacy and Safety of Adjuvant Giredestrant Compared with Physician’s Choice of Adjuvant Endocrine Monotherapy in Patients with Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer.

Locations

Hobart, Wesley, Adelaide (Kurralta Park)

Diagnosis

Breast cancer

Open for recruitment
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CN1-101

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of CN1

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Recruitment completed
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YH003002

A Study to Evaluate YH003 in Combination With Toripalimab (Anti-PD-1 mAb) in Subjects With Advanced Solid Tumors

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Recruitment completed
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WAMM NHL33

A study to look at the safety and efficacy of Acalabrutinib and Rituximab followed by chemo with or without Autologous stem cell transplant (ASCT) and maintenance Acalabrutinib and Rituximab in fit patients with previously untreated mantle cell lymphoma.

Locations

South Brisbane, Wesley, Chermside

Diagnosis

Lymphoma – B-cell Non Hodgkin’s

Recruitment completed
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SHR-1701-001AUS

A Trial of SHR-1701 in Subjects With Advanced Solid Tumors

Locations

South Brisbane, Wesley, Chermside, Southport

Diagnosis

Advanced solid tumours

Open for recruitment
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AML M22

AMLM22/D1: The International Acute myeloid leukaemia (AML) Platform Consortium (IAPC) trial is a randomised, multi-arm study platform to compare the efficacy of experimental therapies versus standard of care in patients with acute myeloid leukaemia in first complete remission.

Locations

South Brisbane, Wesley, Chermside, Southport

Diagnosis

Leukaemia

Open for recruitment
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Destiny 12_D9673C00007

An Open-Label, Multinational, Multicenter, Phase 3b/4 Study of Trastuzumab Deruxtecan in Patients With or Without Baseline Brain Metastasis With Previously Treated Advanced/Metastatic HER2-Positive Breast Cancer (DESTINY-Breast12)

Locations

Wesley

Diagnosis

Breast cancer

Opening soon
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AtTEnd

Atezolizumab Trial in Endometrial Cancer – AtTEnd (AtTEnd)

Locations

South Brisbane, Wesley, Chermside, Southport

Diagnosis

Endometrial cancer

Open for recruitment
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ALLG NBCR

Australasian Leukaemia and Lymphoma Group National Blood Cancer Registry

Locations

Wesley

Diagnosis

Leukaemia

Open for recruitment
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DREAMM 8_207449

Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma (DREAMM 8)

Locations

South Brisbane, Wesley, Chermside, Southport

Diagnosis

Multiple myeloma

Open for recruitment
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CAPItello-291

Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer (CAPItello-291)

Locations

Wesley, Adelaide (Kurralta Park)

Diagnosis

Breast cancer

Open for recruitment
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LIBERATE

Clinical registry of focal low dose rate brachytherapy in men with biopsy confirmed low-intermediate risk prostate cancer

Locations

Epworth Richmond, Epworth Freemasons, Geelong

Diagnosis

Prostate cancer

Open for recruitment
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DASL-HiCaP

Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate (DASL-HiCaP)

Locations

Gold Coast University Hospital, Adelaide (Windsor Gardens)

Diagnosis

Prostate cancer

Open for recruitment
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DREAM3R

DuRvalumab With chEmotherapy as First Line treAtment in Advanced Pleural Mesothelioma (DREAM3R)

Locations

South Brisbane, Wesley, Chermside, Southport

Diagnosis

Mesothelioma

Open for recruitment
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Commands_ACE-536-MDS-002

Efficacy and Safety Study of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in ESA Naïve Subjects Who Require Red Blood Cell Transfusions (COMMANDS)

Locations

South Brisbane, Wesley, Chermside, Southport

Diagnosis

Anaemia

Open for recruitment
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NORTH CP-MGA271-06

Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer

Locations

Southport

Diagnosis

Head and neck cancer

Open for recruitment
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PHI-101-001

Evaluation of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PHI 101 for the Treatment of AML

Locations

Wesley

Diagnosis

Leukaemia

Open for recruitment
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EXPERT

EXamining PErsonalised Radiation Therapy for Low-risk Early Breast Cancer (EXPERT)

Locations

Epworth Richmond

Diagnosis

Breast cancer

Open for recruitment
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ERUPT

External beam Radiotherapy and Urethral strictures in Prostate cancer Treatment

Locations

Toowoomba

Diagnosis

Prostate cancer

Open for recruitment
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MER-XMT-1536-1

First-in-Human Study of XMT-1536 in Cancers Likely to Express NaPi2b

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Open for recruitment
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FPT155-001

FPT155 in Patients With Advanced Solid Tumors (FPT155-001)

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Recruitment completed
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I-MAT

Immunotherapy Adjuvant Trial in Patients With Stage I-III Merkel Cell Carcinoma

Locations

Hobart

Diagnosis

Skin cancer – non-melanoma

Open for recruitment
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BOREAS_KRT-232-101

KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment (BOREAS)

Locations

South Brisbane, Wesley

Diagnosis

Myeloproliferative disorders

Open for recruitment
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MAX-10181-001

MAX-10181 Given Orally to Patients With Advanced Solid Tumor

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Open for recruitment
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MASTERPLAN

MFOLFIRINOX And Stereotactic Radiotherapy (SBRT) for Pancreatic Cancer With High Risk and Locally Advanced Disease (MASTERPLAN)

Locations

Gold Coast University Hospital

Diagnosis

Pancreatic cancer

Open for recruitment
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MRDR

Myeloma and Related Disease Registry

Locations

Wesley, South Brisbane, Chermside, Southport

Diagnosis

Multiple myeloma

Open for recruitment
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ORBIT-m

Optimal Response Biome for ImmunoTherapy in Melanoma

Locations

Hobart

Diagnosis

Skin cancer – melanoma

Recruitment completed
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PNH Registry

Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry

Locations

Wesley

Diagnosis

Paroxysmal Nocturnal Haemoglobinuria (PNH)

Open for recruitment
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CK301-101

Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers

Locations

South Brisbane, Adelaide (Windsor Gardens)

Diagnosis

Advanced solid tumours

Open for recruitment
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AK117-101

Phase 1, Dose Escalation and Dose Expansion Study of AK117, a CD47-targeting Antibody

Locations

South Brisbane, Adelaide (Kurralta Park)

Diagnosis

Advanced solid tumours

Open for recruitment
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ESCALADE

Phase 3 randomized, double-blind, placebo-controlled, study assessing the efficacy and safety of acalabrutinib plus rituximab,cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) vs placebo plus R-CHOP in subjects ≤65 years of age with previously untreated non-germinal center diffuse large B-cell lymphoma.

Locations

South Brisbane, Wesley, Chermside, Southport

Diagnosis

Lymphoma – B-cell Non Hodgkin’s

Open for recruitment
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BAY 88-8223

Radium-223 Dichloride (BAY88-8223) in Castration-Resistant (Hormone-Refractory) Prostate Cancer Patients With Bone Metastases

Locations

Chermside, Wesley, South Brisbane

Diagnosis

Prostate cancer

Open for recruitment
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TREMOR

Safety and effectiveness of frameless linac-based stereotactic radiosurgery on tremor in patients with essential tremor or Parkinson’s disease (TREMOR study)

Locations

Epworth Richmond

Diagnosis

Open for recruitment
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AVATAR

Stereotactic Radiotherapy for Oligoprogressive ER-positive Breast Cancer

Locations

Gold Coast University Hospital, Epworth Richmond

Diagnosis

Breast cancer

Open for recruitment
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HBI-8000-303

Study Comparing Investigational Drug HBI-8000 Combined With Nivolumab vs. Nivolumab in Patients With Advanced Melanoma

Locations

Wesley

Diagnosis

Skin cancer – melanoma

Open for recruitment
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BGB-3111-306 Mangrove

Study Comparing Zanubrutinib + Rituximab Versus Bendamustine + Rituximab in Participants With Untreated Mantle Cell Lymphoma

Locations

Chermside, Wesley, Southport, South Brisbane

Diagnosis

Lymphoma – B-cell Non Hodgkin’s

Open for recruitment
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ICON9

Study Evaluating the Efficacy of Maintenance Olaparib and Cediranib or Olaparib Alone in Ovarian Cancer Patients (ICON9)

Locations

South Brisbane, Wesley, Chermside

Diagnosis

Ovarian cancer

Open for recruitment
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C-POST R2810-ONC-1788

Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma

Locations

Southport

Diagnosis

Skin cancer – non-melanoma

Open for recruitment
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BGB-900-105

Study of BGB-A1217 in Combination With Tislelizumab in Advanced Solid Tumors

Locations

South Brisbane, Adelaide (Windsor Gardens)

Diagnosis

Advanced solid tumours

Open for recruitment
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COSTAR_213410

Study of Cobolimab in Combination With Dostarlimab and Docetaxel in Advanced NSCLC Participants (COSTAR Lung)

Locations

North Lakes, Chermside, Wesley, Southport, South Brisbane

Diagnosis

Lung cancer

Open for recruitment
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MANIFEST-2 CP-0610-04

Study of CPI-0610 in Myelofibrosis (MF) (MANIFEST-2)

Locations

South Brisbane, Chermside, Wesley, Southport

Diagnosis

Myeloproliferative disorders

Open for recruitment
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CYH33-G102

Study of CYH33 in Combination With Olaparib an Oral PARP Inhibitor in Patients With Advanced Solid Tumors.

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Open for recruitment
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EVOKE-01

Study of Sacituzumab Govitecan-hziy (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Progression on or After Platinum-Based Chemotherapy and Anti-programmed Death Protein 1 (PD-1)/Programmed Death Ligand 1 (PD-L1) Immunotherapy

Locations

Hobart

Diagnosis

Lung cancer

Open for recruitment
View Trial

SHRINC

Study to assess the neurological and cognitive effects of using Hypofractionated Stereotactic Radiotherapy used to treat multiple (3-10) brain metastases.

Locations

Epworth Richmond

Diagnosis

Brain cancer

Open for recruitment
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PIVOT-12_CA045-022

Study to Compare Adjuvant Immunotherapy of Bempegaldesleukin Combined With Nivolumab Versus Nivolumab After Complete Resection of Melanoma in Patients at High Risk for Recurrence (PIVOT-12)

Locations

Wesley, Chermside, South Brisbane, Southport

Diagnosis

Skin cancer – melanoma

Recruitment completed
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M19-345

Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination With ABBV-181 in Participants With Locally Advanced or Metastatic Solid Tumors

Locations

South Brisbane

Diagnosis

Advanced solid tumours

Open for recruitment
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TALAPRO-2_C3441021

Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC (TALAPRO-2)

Locations

South Brisbane, Wesley, Chermside

Diagnosis

Prostate cancer

Open for recruitment
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MAGMA

The Multi-Arm GlioblastoMa Australasia (MAGMA) Trial is a platform trial that will assess a number of options in standard of care for the management of glioblastoma. Initial questions of interest are: QUESTION 1 whether or not to give a cycle of temozolomide prior to chemoradiotherapy and QUESTION 2: whether to give 6 or 12 cycles of temozolomide after chemoradiotherapy.

Locations

Gold Coast University Hospital

Diagnosis

Brain cancer

Open for recruitment
View Trial

We are always introducing new clinical trials across our international network. If you can’t find what you are looking for please don’t hesitate to speak to your doctor to learn more, or contact us here.

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