We are always introducing new clinical trials across our international network. If you can’t find what you are looking for please don’t hesitate to speak to your doctor to learn more, or contact us here.


Find a trial
At Icon, we offer clinical trials across various tumour types and blood disorders, allowing patients access to new and emerging advances in treatment, find a trial that might be suitable for you.
Use the search function below to find a clinical trial that may suit you and your cancer diagnosis
EMBRACE
A clinical research study testing olaparib, in Homologous recombination (HR) deficient metastatic breast and relapsed ovarian cancer in patients who do not have hereditary mutations in BReast CAncer susceptibility gene 1 and gene 2 (BRCA1 and BRCA2)
Locations
Wesley, Southport, South Brisbane, Chermside
Diagnosis
Breast cancer, Ovarian cancer
SPAR
A clinical trial comparing Simvastatin to placebo, in addition to standard chemotherapy and radiotherapy, in preoperative treatment for patients with rectal cancer.
Locations
Gold Coast University Hospital
Diagnosis
Colorectal cancer
OP-1250-001
A Dose Escalation/Expansion Study of Oral OP-1250 in Subjects With Advanced and/or Metastatic HR+, HER2- Breast Cancer
Locations
Wesley
Diagnosis
Breast cancer
RLY-4008-101
A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients With Intrahepatic Cholangiocarcinoma (ICC) and Other Advanced Solid Tumors
Locations
South Brisbane
Diagnosis
Advanced solid tumours
OP-1250-002
A Phase 1 Dose Escalation and Expansion Open-label, Multicenter, Study of OP-1250 in Combination With the CDK4/6 Inhibitor Palbociclib in Adult Subjects With Advanced or Metastatic HR-positive, HER2-negative Breast Cancer
Locations
Wesley
Diagnosis
Breast cancer
ABILITY
A Phase 1/2 Open Label, Dose Escalation and Expansion Study of MDNA11, IL-2 Superkine, Administered Alone or in Combination With Immune Checkpoint Inhibitor in Patients With Advanced Solid Tumors.
Locations
South Brisbane
Diagnosis
Advanced solid tumours
DB-1303-O-1001
A Phase 1/2a, Multicenter, Open-Label, Non-Randomized First in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of DB-1303 in Patients With Advanced/Metastatic Solid Tumors
Locations
South Brisbane
Diagnosis
Advanced solid tumours
BGB-290-103
A Phase 1b Study to Assess the Safety, Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Subjects With Locally Advanced or Metastatic Solid Tumors.
Locations
South Brisbane, Adelaide (Kurralta Park)
Diagnosis
Advanced solid tumours
UPLIFT MER-XMT-1536-1
A Phase 1b/2, First-in-Human, Dose Escalation and Expansion Study of XMT-1536 In Patients With Solid Tumors Likely to Express NaPi2b
Locations
South Brisbane
Diagnosis
Ovarian cancer
CodeBreak-101 20190135
A Phase 1b/2, Protocol Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Sotorasib Monotherapy and in Combination With Other Anti-cancer Therapies in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation
Locations
South Brisbane
Diagnosis
Advanced solid tumours
ACT001-AU-004
A Phase 2 clinical trial to assess the safety and efficacy of ACT001 in combination with whole brain radiation therapy (WBRT) for participants with brain metastases from solid tumours.
Locations
Epworth Richmond, Moreland
Diagnosis
Brain cancer
DESTINY-PanTumor02 D967VC00001
A Phase 2, Multicenter, Open-label Study to Evaluate the Efficacy and Safety of Trastuzumab Deruxtecan (T-DXd, DS-8201a) for the Treatment of Selected HER2 Expressing Tumors
Locations
South Brisbane, Wesley
Diagnosis
Advanced solid tumours
TL-895-201
A Phase 2, Open-label, Multicenter Study of TL-895 in Subjects With Relapsed/Refractory Myelofibrosis, Janus Kinase Inhibitor Intolerant Myelofibrosis and Janus Kinase Inhibitor Treatment Ineligible Myelofibrosis
Locations
South Brisbane, Wesley, Chermside, Southport
Diagnosis
Myeloproliferative disorders
BRUIN MCL-321
A Phase 3 Open-Label, Randomized Study of LOXO-305 Versus Investigator Choice of BTK Inhibitor in Patients With Previously Treated BTK Inhibitor Naïve Mantle Cell Lymphoma
Locations
Wesley
Diagnosis
Lymphoma – Hodgkin’s
SHR-2002-102
A Phase I Clinical Study on the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of SHR-2002 Injection in Combination With SHR-1316 in Patients With Advanced Malignant Tumors
Locations
South Brisbane
Diagnosis
Advanced solid tumours
LM108-01-101
A Phase I/II, First-in-Human (FIH), Open-Label, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of LM-108 as a Single Agent or in Combination With Anti-PD-1 Antibody in Subjects With Advanced Solid Tumours
Locations
South Brisbane
Diagnosis
Advanced solid tumours
SUCCEED_MG010-001
A phase I/II, open label, multi-centre study to assess the safety, tolerability, and efficacy of MG010 in combination with sorafenib in subjects with solid tumours who have failed existing treatments.
Locations
South Brisbane, Wesley, Chermside, Southport
Diagnosis
Advanced solid tumours
CUPISCO-MX39795
A Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Versus Platinum-Based Chemotherapy in Patients With Cancer of Unknown Primary Site (CUPISCO)
Locations
Southport, Wesley, South Brisbane, Chermside
Diagnosis
Cancer-unknown origin
OUTRUN
A Randomised Phase II Trial of Osimertinib With or Without Stereotactic Radiosurgery for EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) With Brain Metastases
Locations
Greenslopes
Diagnosis
Lung cancer
GCT3013-05
A Randomized, Open-Label, Phase 3 Trial of Epcoritamab vs Investigator’s Choice Chemotherapy in Relapsed/Refractory Diffuse Large B-cell Lymphoma
Locations
South Brisbane, Wesley
Diagnosis
Lymphoma – B-cell Non Hodgkin’s
Impassion030 WO39391 Alexandra
A Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based Chemotherapy Versus Chemotherapy Alone In Patients With Operable Triple-Negative Breast Cancer (IMpassion030)
Locations
Wesley, Adelaide (Kurralta Park)
Diagnosis
Breast cancer
Checkmate-914 CA209-914
A Study Comparing Nivolumab, Nivolumab in Combination With Ipilimumab and Placebo in Participants With Localized Kidney Cancer Who Underwent Surgery to Remove Part of a Kidney (CheckMate 914)
Locations
South Brisbane, Wesley, Chermside
Diagnosis
Kidney cancer
AK112-101
A Study of AK112, a PD-1/VEGF Bispecific Antibody, for Advanced Solid Tumors
Locations
South Brisbane, Adelaide (Kurralta Park)
Diagnosis
Advanced solid tumours
AK119-102
A Study of AK119 (Anti-CD73) in Combination With AK104 in Subjects With Advanced Solid Tumors
Locations
South Brisbane, Adelaide (Kurralta Park)
Diagnosis
Advanced solid tumours
CONTACT-03 WO41994
A Study of Atezolizumab in Combination With Cabozantinib Compared to Cabozantinib Alone in Participants With Advanced Renal Cell Carcinoma After Immune Checkpoint Inhibitor Treatment (CONTACT-03)
Locations
South Brisbane, Wesley, Chermside, Southport
Diagnosis
Kidney cancer
RAGNAR 42756493CAN2002
A Study of Erdafitinib in Participants With Advanced Solid Tumors and Fibroblast Growth Factor Receptor (FGFR) Gene Alterations
Locations
South Brisbane, Wesley, Chermside, Southport
Diagnosis
Advanced solid tumours
67652000PCR3002 AMPLITUDE
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) (AMPLITUDE)
Locations
Chermside, South Brisbane, Southport, Wesley
Diagnosis
Prostate cancer
Checkmate-7DX_CA209-7DX
A Study of Nivolumab or Placebo in Combination With Docetaxel in Men With Advanced Castration-resistant Prostate Cancer (CheckMate 7DX)
Locations
Chermside, Wesley, South Brisbane, Southport
Diagnosis
Prostate cancer
CA224-104
A Study of Relatlimab Plus Nivolumab in Combination With Chemotherapy vs. Nivolumab in Combination With Chemotherapy as First Line Treatment for Participants With Stage IV or Recurrent Non-small Cell Lung Cancer (NSCLC)
Locations
Chermside, North Lakes, Wesley, South Brisbane, Southport
Diagnosis
Lung cancer
TROPiCS-04
A Study of Sacituzumab Govitecan-hziy Versus Treatment of Physician’s Choice in Participants With Metastatic or Locally Advanced Unresectable Urothelial Cancer.
Locations
Hobart, Wesley
Diagnosis
Urothelial cancer
CANOVA M13-494
A Study of Venetoclax and Dexamethasone Compared With Pomalidomide and Dexamethasone in Participants With Relapsed or Refractory Multiple Myeloma (CANOVA)
Locations
South Brisbane, Southport, Townsville, Wesley, Chermside
Diagnosis
Multiple myeloma
ABSK043-101
A Study to Assess Safety, Tolerability, and Pharmacokinetics of ABSK043 in Patients With Advanced Solid Tumor
Locations
South Brisbane
Diagnosis
Advanced solid tumours
M19-037
A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors
Locations
South Brisbane, Wesley
Diagnosis
Advanced solid tumours, Breast cancer
liDERA
A study to evaluate the Efficacy and Safety of Adjuvant Giredestrant Compared with Physician’s Choice of Adjuvant Endocrine Monotherapy in Patients with Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer.
Locations
Hobart, Wesley, Adelaide (Kurralta Park)
Diagnosis
Breast cancer
CN1-101
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of CN1
Locations
South Brisbane
Diagnosis
Advanced solid tumours
YH003002
A Study to Evaluate YH003 in Combination With Toripalimab (Anti-PD-1 mAb) in Subjects With Advanced Solid Tumors
Locations
South Brisbane
Diagnosis
Advanced solid tumours
WAMM NHL33
A study to look at the safety and efficacy of Acalabrutinib and Rituximab followed by chemo with or without Autologous stem cell transplant (ASCT) and maintenance Acalabrutinib and Rituximab in fit patients with previously untreated mantle cell lymphoma.
Locations
South Brisbane, Wesley, Chermside
Diagnosis
Lymphoma – B-cell Non Hodgkin’s
SHR-1701-001AUS
A Trial of SHR-1701 in Subjects With Advanced Solid Tumors
Locations
South Brisbane, Wesley, Chermside, Southport
Diagnosis
Advanced solid tumours
AML M22
AMLM22/D1: The International Acute myeloid leukaemia (AML) Platform Consortium (IAPC) trial is a randomised, multi-arm study platform to compare the efficacy of experimental therapies versus standard of care in patients with acute myeloid leukaemia in first complete remission.
Locations
South Brisbane, Wesley, Chermside, Southport
Diagnosis
Leukaemia
Destiny 12_D9673C00007
An Open-Label, Multinational, Multicenter, Phase 3b/4 Study of Trastuzumab Deruxtecan in Patients With or Without Baseline Brain Metastasis With Previously Treated Advanced/Metastatic HER2-Positive Breast Cancer (DESTINY-Breast12)
Locations
Wesley
Diagnosis
Breast cancer
AtTEnd
Atezolizumab Trial in Endometrial Cancer – AtTEnd (AtTEnd)
Locations
South Brisbane, Wesley, Chermside, Southport
Diagnosis
Endometrial cancer
ALLG NBCR
Australasian Leukaemia and Lymphoma Group National Blood Cancer Registry
Locations
Wesley
Diagnosis
Leukaemia
DREAMM 8_207449
Belantamab Mafodotin Plus Pomalidomide and Dexamethasone (Pd) Versus Bortezomib Plus Pd in Relapsed/Refractory Multiple Myeloma (DREAMM 8)
Locations
South Brisbane, Wesley, Chermside, Southport
Diagnosis
Multiple myeloma
CAPItello-291
Capivasertib+Fulvestrant vs Placebo+Fulvestrant as Treatment for Locally Advanced (Inoperable) or Metastatic HR+/HER2- Breast Cancer (CAPItello-291)
Locations
Wesley, Adelaide (Kurralta Park)
Diagnosis
Breast cancer
LIBERATE
Clinical registry of focal low dose rate brachytherapy in men with biopsy confirmed low-intermediate risk prostate cancer
Locations
Epworth Richmond, Epworth Freemasons, Geelong
Diagnosis
Prostate cancer
DASL-HiCaP
Darolutamide Augments Standard Therapy for Localised Very High-Risk Cancer of the Prostate (DASL-HiCaP)
Locations
Gold Coast University Hospital, Adelaide (Windsor Gardens)
Diagnosis
Prostate cancer
DREAM3R
DuRvalumab With chEmotherapy as First Line treAtment in Advanced Pleural Mesothelioma (DREAM3R)
Locations
South Brisbane, Wesley, Chermside, Southport
Diagnosis
Mesothelioma
Commands_ACE-536-MDS-002
Efficacy and Safety Study of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low or Intermediate Risk Myelodysplastic Syndromes (MDS) in ESA Naïve Subjects Who Require Red Blood Cell Transfusions (COMMANDS)
Locations
South Brisbane, Wesley, Chermside, Southport
Diagnosis
Anaemia
NORTH CP-MGA271-06
Enoblituzumab Plus Retifanlimab or Tebotelimab in Head and Neck Cancer
Locations
Southport
Diagnosis
Head and neck cancer
PHI-101-001
Evaluation of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PHI 101 for the Treatment of AML
Locations
Wesley
Diagnosis
Leukaemia
EXPERT
EXamining PErsonalised Radiation Therapy for Low-risk Early Breast Cancer (EXPERT)
Locations
Epworth Richmond
Diagnosis
Breast cancer
ERUPT
External beam Radiotherapy and Urethral strictures in Prostate cancer Treatment
Locations
Toowoomba
Diagnosis
Prostate cancer
MER-XMT-1536-1
First-in-Human Study of XMT-1536 in Cancers Likely to Express NaPi2b
Locations
South Brisbane
Diagnosis
Advanced solid tumours
FPT155-001
FPT155 in Patients With Advanced Solid Tumors (FPT155-001)
Locations
South Brisbane
Diagnosis
Advanced solid tumours
I-MAT
Immunotherapy Adjuvant Trial in Patients With Stage I-III Merkel Cell Carcinoma
Locations
Hobart
Diagnosis
Skin cancer – non-melanoma
BOREAS_KRT-232-101
KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment (BOREAS)
Locations
South Brisbane, Wesley
Diagnosis
Myeloproliferative disorders
MAX-10181-001
MAX-10181 Given Orally to Patients With Advanced Solid Tumor
Locations
South Brisbane
Diagnosis
Advanced solid tumours
MASTERPLAN
MFOLFIRINOX And Stereotactic Radiotherapy (SBRT) for Pancreatic Cancer With High Risk and Locally Advanced Disease (MASTERPLAN)
Locations
Gold Coast University Hospital
Diagnosis
Pancreatic cancer
MRDR
Myeloma and Related Disease Registry
Locations
Wesley, South Brisbane, Chermside, Southport
Diagnosis
Multiple myeloma
ORBIT-m
Optimal Response Biome for ImmunoTherapy in Melanoma
Locations
Hobart
Diagnosis
Skin cancer – melanoma
PNH Registry
Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry
Locations
Wesley
Diagnosis
Paroxysmal Nocturnal Haemoglobinuria (PNH)
CK301-101
Phase 1 Study of CK-301 (Cosibelimab) as a Single Agent in Subjects With Advanced Cancers
Locations
South Brisbane, Adelaide (Windsor Gardens)
Diagnosis
Advanced solid tumours
AK117-101
Phase 1, Dose Escalation and Dose Expansion Study of AK117, a CD47-targeting Antibody
Locations
South Brisbane, Adelaide (Kurralta Park)
Diagnosis
Advanced solid tumours
ESCALADE
Phase 3 randomized, double-blind, placebo-controlled, study assessing the efficacy and safety of acalabrutinib plus rituximab,cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) vs placebo plus R-CHOP in subjects ≤65 years of age with previously untreated non-germinal center diffuse large B-cell lymphoma.
Locations
South Brisbane, Wesley, Chermside, Southport
Diagnosis
Lymphoma – B-cell Non Hodgkin’s
BAY 88-8223
Radium-223 Dichloride (BAY88-8223) in Castration-Resistant (Hormone-Refractory) Prostate Cancer Patients With Bone Metastases
Locations
Chermside, Wesley, South Brisbane
Diagnosis
Prostate cancer
TREMOR
Safety and effectiveness of frameless linac-based stereotactic radiosurgery on tremor in patients with essential tremor or Parkinson’s disease (TREMOR study)
Locations
Epworth Richmond
Diagnosis
AVATAR
Stereotactic Radiotherapy for Oligoprogressive ER-positive Breast Cancer
Locations
Gold Coast University Hospital, Epworth Richmond
Diagnosis
Breast cancer
HBI-8000-303
Study Comparing Investigational Drug HBI-8000 Combined With Nivolumab vs. Nivolumab in Patients With Advanced Melanoma
Locations
Wesley
Diagnosis
Skin cancer – melanoma
BGB-3111-306 Mangrove
Study Comparing Zanubrutinib + Rituximab Versus Bendamustine + Rituximab in Participants With Untreated Mantle Cell Lymphoma
Locations
Chermside, Wesley, Southport, South Brisbane
Diagnosis
Lymphoma – B-cell Non Hodgkin’s
ICON9
Study Evaluating the Efficacy of Maintenance Olaparib and Cediranib or Olaparib Alone in Ovarian Cancer Patients (ICON9)
Locations
South Brisbane, Wesley, Chermside
Diagnosis
Ovarian cancer
C-POST R2810-ONC-1788
Study of Adjuvant Cemiplimab Versus Placebo After Surgery and Radiation Therapy in Patients With High Risk Cutaneous Squamous Cell Carcinoma
Locations
Southport
Diagnosis
Skin cancer – non-melanoma
BGB-900-105
Study of BGB-A1217 in Combination With Tislelizumab in Advanced Solid Tumors
Locations
South Brisbane, Adelaide (Windsor Gardens)
Diagnosis
Advanced solid tumours
COSTAR_213410
Study of Cobolimab in Combination With Dostarlimab and Docetaxel in Advanced NSCLC Participants (COSTAR Lung)
Locations
North Lakes, Chermside, Wesley, Southport, South Brisbane
Diagnosis
Lung cancer
MANIFEST-2 CP-0610-04
Study of CPI-0610 in Myelofibrosis (MF) (MANIFEST-2)
Locations
South Brisbane, Chermside, Wesley, Southport
Diagnosis
Myeloproliferative disorders
CYH33-G102
Study of CYH33 in Combination With Olaparib an Oral PARP Inhibitor in Patients With Advanced Solid Tumors.
Locations
South Brisbane
Diagnosis
Advanced solid tumours
EVOKE-01
Study of Sacituzumab Govitecan-hziy (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) With Progression on or After Platinum-Based Chemotherapy and Anti-programmed Death Protein 1 (PD-1)/Programmed Death Ligand 1 (PD-L1) Immunotherapy
Locations
Hobart
Diagnosis
Lung cancer
SHRINC
Study to assess the neurological and cognitive effects of using Hypofractionated Stereotactic Radiotherapy used to treat multiple (3-10) brain metastases.
Locations
Epworth Richmond
Diagnosis
Brain cancer
PIVOT-12_CA045-022
Study to Compare Adjuvant Immunotherapy of Bempegaldesleukin Combined With Nivolumab Versus Nivolumab After Complete Resection of Melanoma in Patients at High Risk for Recurrence (PIVOT-12)
Locations
Wesley, Chermside, South Brisbane, Southport
Diagnosis
Skin cancer – melanoma
M19-345
Study to Determine the Safety, Tolerability, Pharmacokinetics and RP2D of ABBV-151 as a Single Agent and in Combination With ABBV-181 in Participants With Locally Advanced or Metastatic Solid Tumors
Locations
South Brisbane
Diagnosis
Advanced solid tumours
TALAPRO-2_C3441021
Talazoparib + Enzalutamide vs. Enzalutamide Monotherapy in mCRPC (TALAPRO-2)
Locations
South Brisbane, Wesley, Chermside
Diagnosis
Prostate cancer
MAGMA
The Multi-Arm GlioblastoMa Australasia (MAGMA) Trial is a platform trial that will assess a number of options in standard of care for the management of glioblastoma. Initial questions of interest are: QUESTION 1 whether or not to give a cycle of temozolomide prior to chemoradiotherapy and QUESTION 2: whether to give 6 or 12 cycles of temozolomide after chemoradiotherapy.
Locations
Gold Coast University Hospital
Diagnosis
Brain cancer