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PO Box 3787

South Brisbane QLD 4101

Dr Nat Lenzo

Clinical Director (Asia Pacific): Molecular Imaging and Nuclear Oncology BMedSci(Hons), BSc, MBBS, MMed, MSc(Oncol), FRACP, FAANMS

  • Nuclear Medicine Physician

Biography

Dr Nat Lenzo is a highly experienced and internationally recognised Nuclear Medicine Physician with more than 25 years’ experience in specialised nuclear oncology.

Dr Lenzo completed his Bachelor of Medicine, Bachelor of Surgery (MBBS) at the University of Western Australia. He received advanced training in general and nuclear medicine at Fremantle, Sir Charles Gairdner and Royal Perth Hospitals, and subsequently completed a fellowship in nuclear medicine at the University of Michigan. He is a Fellow of the Royal Australian College of Physicians (FRACP) and Australasian Association of Nuclear Medicine Specialists (FAANMS).

In 2015, Dr Lenzo founded Theranostics Australia, the nation’s first private theranostics practice, where he worked as a group clinical director and expanded the field of nuclear oncology globally. He has held notable positions including Head of Nuclear Medicine at Royal Perth Hospital, Head of the Western Australia PET Cyclotron Service at Sir Charles Gairdner Hospital, and Head of General Medicine at Fremantle Hospital. He is also the Founding Director of Cyclowest, a start-up company with a strong focus on patient care and cutting-edge innovative molecular imaging research to help bring the latest diagnostic and therapeutic radiopharmaceuticals to Perth and the Asia-Pacific region.

Alongside his practice at Icon, Dr Lenzo is an adjunct Clinical Professor in Medicine at Curtin University and Notre Dame University Australia and consultant physician at St John of God Hospital Murdoch. He is a Board Member at radiopharmaceutical company, Glytherix, and holds advisory Roles with Telix Pharmaceuticals, Novartis Australia, 3BP, ANSTO and the University of Queensland Centre for Advanced Imaging.

Dr Lenzo maintains a strong interest in clinical research and has co-authored over 60 peer-reviewed publications specialising in molecular imaging and targeted therapies.

He treats at Icon Cancer Centre North Lakes, with a view to begin treating more patients across the eastern seaboard and at Icon’s Singapore locations and beyond.

Publications

Nguyen, H., Hird, K., Cardaci, J., Smith, S., & Lenzo, N. P. (2024). Lutetium-177 Labelled Anti-PSMA Monoclonal Antibody (Lu-TLX591) Therapy for Metastatic Prostate Cancer: Treatment Toxicity and Outcomes. Molecular diagnosis & therapy, 10.1007/s40291-024-00699-w. Advance online publication.

Lenzo, N., O’Byrne, K., Ngai, S., Meyrick, D., Patel, N., Hayward, C. (2024). Journal of Clinical Oncology 42 (4_suppl), TPS253-TPS253. Safety, tolerability, and dosimetry of 177Lu-TLX591 with best standard of care in patients with PSMA-expressing metastatic castration-resistant prostate cancer. 

Hawkins, C., Lenzo, N., Gibson, J., Brown, T., Patel, N., Martina, S., Hayward, C. (2024). ProstACT GLOBAL: A phase 3 study of best standard of care with and without 177Lu-DOTA-rosopatamab (TLX591) for patients with PSMA expressing metastatic.

Sathekge, MM., Lawal, IO., Bal, C., Bruchertseifer, F., Ballal, S., Cardaci, G. (2024). The Lancet Oncology 25 (2), 175-183.Actinium-225-PSMA radioligand therapy of metastatic castration-resistant prostate cancer (WARMTH Act): a multicentre, retrospective study.

Lenzo, N. (2024). Theranostics in Australia: The Importance of Vision and Training, and the Power of Collaboration. 

Research

Trials being conducted by this doctor

ATNM-400-001

This is a 3-part, multicentre, open-label Phase 1 study of ATNM-400 in men with metastatic castrate-resistant prostate cancer (mCRPC).Part A – Imaging Lead-in ([89Zr]-barecetamab-DFO):Up to 10 participants will receive a single intravenous (IV) dose of [89Zr]-barecetamab-DFO at approximately 37 MBq (1 mCi) for imaging-only purposes. This radio-labelled antibody is a non-therapeutic surrogate of ATNM-400 and is used to assess tumor targeting, biodistribution, dosimetry, and pharmacokinetics. PET/CT imaging will be performed at multiple time points (2–336 hours post-dose) to determine organ and tumor uptake and confirm radiation safety for subsequent therapeutic dosing.All imaging doses will be prepared and administered by qualified nuclear medicine personnel (radiopharmacists, radiologists, or technologists) at participating sites in compliance with radiation safety regulationsPart B – ATNM-400 Dose Escalation:Eligible participants will receive ATNM-400 ([225Ac]-barecetamab-DOTA) as an intravenous infusion on Day 1 of each 42-day treatment cycle, for up to four cycles. Dose escalation will follow a traditional 3+3 design across five planned cohorts, with dose levels ranging from 1.0 µCi/kg (0.037 MBq/kg) to 3.0 µCi/kg (0.11 MBq/kg). The infusion will be administered over approximately 30 minutes. Dose-limiting toxicities (DLTs) will be evaluated by the Safety Review Committee (SRC) to determine the maximum tolerated dose. Participants from Part A who demonstrate tumour uptake and meet eligibility criteria may re-enroll into Part B.Part C – ATNM-400 Dose Expansion:Approximately 18 participants will receive ATNM-400 at the maximum tolerated dose (MTD) determined in Part B. Part C will begin after the final participant in Part B has completed the DLT observation period and the SRC has confirmed the MTD, which is typically within two to four weeks after the last Part B participant’s DLT window. Participants from Part B will not be re-treated in Part C; only newly enrolled participants will receive expansion dosing. ATNM-400 will be administered as an intravenous infusion on Day 1 of each 42-day treatment cycle for up to four cycles. Each cycle may be extended to 56 days if additional time is required for haematological recovery, although dosing will continue to occur once per cycle regardless of cycle length.

Locations Hollywood

Diagnosis Prostate cancer