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07 3737 4500

PO Box 3787

South Brisbane QLD 4101

Dr Karthik Nath

MBBS (Hons), BSc, FRACP, FRCPA, PhD

  • Clinical Haematologist
South Brisbane
07 3737 4736 07 3737 4701

Biography

Incredibly passionate about both research and clinical practice, Dr Karthik Nath incorporates the latest advancements in haematology to ensure the best outcomes for his patients. Dr Nath’s approach is rooted in empathy, respect, and a deep commitment to improving the quality of life for his patients, and ensuring they receive the highest standard of personalised care in a supportive environment.

Dr Karthik Nath is a clinical haematologist at Icon Cancer Centre in South Brisbane, with a strong background in clinical practice and research aimed at advancing the field of haematology and enhancing patient outcomes. He is also Icon’s Deputy Director of Cellular Therapy. Dr Nath also provides weekly consultations services at Brisbane South Private Hospital, Springwood Health Hub in Springwood and monthly consultation services at The Friendlies Medical Suites in Bundaberg.

Dr Nath received his Bachelor of Science (BSc) and Bachelor of Medicine, Bachelor of Surgery (MBBS) with Honours from the University of Queensland (UQ) in Brisbane, Australia. Following his internship at Princess Alexandra Hospital, he served as an Internal Medicine Registrar at Metro South Health Service and completed his Haematology and Hematopathology Fellowships at The Townsville Hospital and the Royal Brisbane & Women’s Hospital.

In addition to clinical training, Dr Nath earned a PhD in Lymphoma biology from the Faculty of Medicine at UQ, which was supported by the prestigious Leukaemia Foundation / HSANZ Scholarship. He then completed a clinical fellowship at Icon Cancer Centre before relocating to the US to pursue the Parker Institute for Cancer Immunotherapy advanced fellowship at Memorial Sloan Kettering Cancer Center (MSK) in New York. Following this, Dr. Nath was recruited as a consultant haematologist in the MSK Cellular Therapy Service, where he oversaw the management of patients receiving novel cellular therapies such as CAR T-cell therapy and tumour infiltrating lymphocytes (TILs).

Dr Nath’s expertise encompasses a broad range of blood disorders, including leukaemia, lymphoma, multiple myeloma, stem cell transplantation, cellular immunotherapy, thrombosis and haemostasis, and general haematology. His research focuses on cellular immunotherapy for the treatment of blood cancers and he is a strong advocate for clinical trials.

Dr Nath has been fortunate to be supported with awards/honours for his work in clinical haematology and has presented his work at prestigious international conferences. He has had the distinct pleasure of publishing his work in leading peer-reviewed medical journals, including first author publications in Nature Medicine and Blood, reflecting his commitment to optimising treatment modalities and patient outcomes in haematology. He holds specialist certificates from Harvard Medical School, USA and the European School of Oncology, Ulm University, Germany.

Fluent in English and Tamil, Dr Nath is dedicated to education, frequently lecturing on topics related to haematology and CAR T-cell therapy.

Publications

  • Comparison of infectious complications with BCMA-directed therapies in multiple myeloma. (2024). Nath, K., Shekarkhand, T., Nemirovsky, D., et al. Blood Cancer Journal. 14, 88.

  • CD19 CAR T-cell therapy and prophylactic anakinra in relapsed or refractory lymphoma: phase 2 trial interim results. (2023). Park, JH., Nath, K., Devlin, SM., et al. Nature Medicine. 2023:2, 1710-1717.

  • Prospective analysis to determine barriers to allogeneic hematopoietic cell transplantation in patients with acute leukemia. (2023). Nath, K., Lee, J., Elko, TA., et al. Am J Hematol. 2023; 1-8.

  • Interventions and outcomes of multiple myeloma patients receiving salvage treatment after BCMA-directed CAR T therapy. (2022). Van Oekelen, O., Nath, K.,  Mouhieddine, TH., et al. Blood. 2022:blood.2022017848.

  • Activity and outcomes of autologous stem cell transplantation in the private sector in Australia. (2023). Nath, K., James, Y., Taylor, D., et al. Internal Med J. 2023.

Research

Trials being conducted by this doctor

M25-059

Multiple myeloma (MM) is a cancer of the blood’s plasma cells. The cancer is typically found in the bones and bone marrow (the spongy tissue inside of the bones) and can cause bone pain, fractures, infections, weaker bones, and kidney failure. Treatments are available, but MM can come back (relapsed) or may not get better (refractory) with treatment. This is a study to determine the safety, efficacy, and pharmacokinetics of Etentamig in adult participants with MM.Etentamig is an investigational drug being developed for the treatment of MM. This study is broken into 4 substudies and each substudy consists of a dose escalation phase and dose expansion phase. Participants will receive escalating doses of etentamig alone or in combination with daratumumab and lenalidomide (DR), carfilzomib and dexamethasone (Kd) or lenalidomide (R). This will be followed by etentamig at the dose levels established during the escalation phases alone or in combination with DR, Kd, R. The participants can also receive daratumumab, lenalidomide and dexamethasone (DRd), R, or daratumumab, carfilzomib, and dexamethasone (DKd) as a comparator in the dose expansion phases. Around 440 adult participants with MM will be enrolled at approximately 50 sites worldwide.In all substudies, participants will receive escalating doses of etentamig as Intravenous (IV) infusions, alone or in combination with DR, R or Kd, followed by IV infusions of etentamig at the dose levels established during the escalation phases alone or in combination with IV and oral DRd, DKd, or R. The study duration is approximately 130 months.There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and questionnaires.

Locations South Brisbane, Wesley

Diagnosis Multiple myeloma