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07 3737 4500

PO Box 3787

South Brisbane QLD 4101

Dr Patrick Bowden

MBBS, FRANZCR

  • Radiation Oncologist
Epworth Richmond
03 9936 8277 03 9978 9427

Biography

Dr Patrick Bowden is committed to providing comprehensive, patient-centred cancer care. He is a highly experienced doctor who remains at the forefront of cutting-edge radiation therapy techniques and clinical research.

Dr Patrick Bowden has more than 20 years’ experience as a radiation oncologist, and is committed to providing comprehensive, patient-centred care by remaining at the forefront of innovative radiation therapy practice. He is based at several Icon Cancer Centre sites including Epworth Freemasons, Epworth Richmond, Moreland, Mulgrave and Canberra.

After establishing his radiation oncology career at Peter MacCallum Cancer Centre, he became director of Tattersall’s Cancer Centre in 2007 (the private arm of Peter MacCallum Cancer Centre). In 2011, he was appointed inaugural Director of Epworth Radiation Oncology. In this role he built Australia’s largest stereotactic radiation therapy service including a clinical trial institute and integrated oncology services at Epworth Freemasons. In 2016, the South West Regional Cancer Centre in Warrnambool was established under his directorship, and he played an integral role in the transition of Epworth Radiation Oncology to Icon Cancer Centre.

Dr Bowden is actively involved in education, medical leadership, research and clinical trials. He was previously a member of the Epworth Medical Advisory Committee from 2007-2016 (maximum allowed 9-year tenure). He is also the Chairman of Access Telehealth; Australia’s largest provider of free consultations to patients in rural and remote areas.

Dr Bowden has been active in numerous clinical trials and acted as principal investigator in key studies investigating radiation therapy treatments for lung, cervix and prostate cancers. In July 2019, his world-leading study TRANSFORM was published in the International Journal of Cancer, evaluating the efficacy of stereotactic radiation therapy for oligometastatic prostate cancer. In June 2021, his PINPOINT study investigating the use of Calypso guidance beacons to reduce prostate radiation therapy side effects was published in the World Journal of Urology. Both Australian studies with the support of Epworth Medical Foundation and EJ Whitten Foundation were the world’s largest clinical trials of their kind. With Dr Andrew See, he was co-investigator on PROSPER-82, the largest trial in Australia using spacing gel to protect the rectum during prostate radiotherapy. This study confirmed that spacing gel eliminates severe bowel damage.

His clinical experience covers a broad range of solid tumour malignancies, with a special interest in urological cancers, gastrointestinal cancer and metastatic cancers.

Research

Trials being conducted by this doctor

POPSTAR II

Metastatic disease in patients involves treatment including systemic chemotherapy, hormonal therapy and androgen deprivation therapy. “Oligometastases” was termed to describe a state of metastatic transition wherein the cancer cells travel from the original site of tumour to other parts of the body and form fewer number of tumours. Sustained systemic therapies such as chemotherapy have been used as the Standard of care (SOC) in most cases. Novel radiotherapy like Lutetium-177 PSMA radionuclide therapy have been explored in earlier disease settings to further improve outcomes. Based on evidence from few previous trials and emerging safety data from ongoing trials, it is an effective addition to SOC to further improve patient outcomes.The detection of prostate cancer can be done by a highly sensitive and specific test using the PSMA-PET small molecules. The evidence of high uptake of these PSMA-PET small molecules assists in selection of patients potentially suitable for novel PSMA targeted radionuclide therapy. Previous studies have demonstrated novel molecular imaging techniques, particularly PSMA PET/CT in the biochemical recurrence setting is leading to an increasing number of patients being diagnosed with oligometastatic disease which would not have been detected using conventional imaging techniques.The Stereotactic ablative body radiotherapy (SABR) is also an emerging localised treatment option for oligometastatic prostate cancer. It delivers a highly focused beam of external radiation concentrated over a tumour and has been used to treat low volume metastatic disease to delay the use of systemic therapies. Results from previous studies show that it a safe, well-tolerated and progressively used in real-world clinical practice to treat patients with low volume of metastatic cancer. Based on the results of a previous trial done by this team, patients with one to three sites of disease treated with a single session of SABR showed promising outcomes.The aim of this trial is to evaluate the progression free survival of SABR alone and SABR + 177Lu-prostate-specific membrane antigen (PSMA) in patients with oligometastatic prostate cancer undergoing PSMA positron emission tomography (PET) staging.92 men with oligometastatic prostate cancer will be enrolled in this trial and split into 1:1 ratio to either stereotactic ablative body radiotherapy (SABR) alone or SABR plus 2 cycles of 177Lu-PSMA over a period of 24 months.

Locations Epworth Richmond, Epworth Freemasons, Moreland, Holmesglen, Mulgrave

Diagnosis Prostate cancer